Stefano Sturaro and Goran Pandev scored Genoa second-half goals to secure Genoa an unlikely 2-0 victory over Juventus, handing the Serie A leaders their first defeat of the season.
Juve are still in pole position to win an eighth consecutive Scudetto – even a Napoli victory later on Sunday would leave the Turin side with a 15-point cushion at the top.
The Old Lady were without Portuguese star, who inspired them to a 3-0 Champions League win over Atletico Madrid on Tuesday.
Meanwhile, Sevilla have announced the return of Monchi as sporting director, ending links to Arsenal. Gunners manager Unai Emery, who previously worked with Monchi at the Spanish club, had been keen to see the 50-year-old installed at the Emirates Stadium.
Monchi, who has a long association with Sevilla stretching back to his playing career, was available after leaving his role as director of football at Italian club Roma this month. A statement from the La Liga club read: “Sevilla FC and Monchi have come to an agreement for the San Fernando native to return to the post he left two years ago – sporting director of Sevilla Football Club.”